Say, as you said you can split the world, roughly, and we are using relatively sweeping, well I'm certainly using relatively sweeping generalisations. But if you were to take a view of the US, Europe, for example, and look at physical inactivity, diet, high blood pressure, tobacco use, high cholesterol, for example, obviously they all have a knock on effect in terms of their cumulative impact on the body. But if you are going to rank these risk factors for people and really give them a starting point as to how they can start to live more healthily and reduce their risk for developing heart disease in the future, how would you go about doing that?
Right, that's an excellent question. So, we know that there are certain things which make a difference and let me try and give you some quite human advice here. For the average person out on the street, let's take me. I’m a mid 40s male who drinks a bit of alcohol. I don't smoke but have previously, I have a diet that I try and manage but sometimes it's not as healthy as it could be, and I try to do exercise. So, I represent the average man who is at risk of cardiovascular risk factor. So what are the things that I would concentrate on for myself? So the first thing is I want to know what my cholesterol and my fat levels are doing. You need blood tests probably once a year, to be able to monitor that, and you want to have your total cholesterol under control. You want to have a high ratio of high density lipoprotein versus low density lipoprotein (HDL versus LDL). You want to have low triglycerides, because triglycerides are not good for you, and you want to generally be avoiding polyunsaturated fats in your diet. So you want to have good fats, you know the salts you get from avocados and things like that, and avoid the bad fats that you get from fried food. That's the most important thing; singularly that's the most important risk factor is getting cholesterol under control. Number two, behind that is don't smoke. Smoking is the second most influential factor in causing heart disease, and people who smoke will have a higher risk, and the more you smoke, the higher the risk. If you're a smoker, this is one of the first things that you just need to stop if you're at risk of heart disease. The third, interestingly, is psychosocial. It's about how much stress, depression, anxiety you have in your life. It’s about the housing that you live in. It's about the social determinants of your health, and the people you surround yourself with that actually comes in pretty close after smoking. It’s almost as important as smoking, so if you live with a lot of stress, depression, mental health issues, in a poor environment that is as bad as smoking almost. It's not as easy to act on, but it's an important factor. The next one is diabetes. So, I'm a South Asian individual, Indian by background. Diabetes runs high in my ethnicity. Type two diabetes, which often is associated with obesity, is the next biggest risk factor, and then behind that it's high blood pressure. So, getting your blood pressure under control, will really help. After that your family history,you can't do much about that but if you've got a strong family history you'd be much more conscious. And then behind that is obesity. Now, obesity is a relatively low risk, compared to say, high cholesterol. But of course the two are linked. And the big problem with the world, forgive the pun, is that obesity is now our single biggest problem. Bigger than COVID, bigger than smoking, bigger than everything else and that's because we are all getting fat and obese. If there's one single macro thing I want to tackle as a policymaker, it is obesity, because I think that will make the most difference in people getting cardiovascular disease.